Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leptin and exercise.

Robert R Kraemer1, Hongnan Chu, V Daniel Castracane

  • 1Department of Kinesiology and Health Studies, Southeastern Louisiana University, Hammond 70402, USA. rkraemer@selu.edu

Experimental Biology and Medicine (Maywood, N.J.)
|September 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endogenous Opioids and Exercise-Related Hypoalgesia: Modern Models, Measurement, and Mechanisms of Action.

Advances in neurobiology·2024
Same author

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis.

Frontiers in endocrinology·2023
Same author

The effects of separate and simultaneous upper and lower body cycling on cardiorespiratory responses in young men.

The Journal of sports medicine and physical fitness·2023
Same author

Maternal serum leptin in the pregnant rat: fetal-placental implantation number and progesterone.

Endocrine·2022
Same author

Perils of prolonged ovarian suppression and hypoestrogenism in the treatment of breast cancer: Is the risk of treatment worse than the risk of recurrence?

Molecular and cellular endocrinology·2021
Same author

Relative energy deficiency in sports (RED-S): elucidation of endocrine changes affecting the health of males and females.

Hormones (Athens, Greece)·2020
Same journal

Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form <i>Trypanosoma brucei brucei</i>.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

High systolic blood pressure and stroke: evidence from the NHANES 1999-2023 and global burden of disease 2021.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis.

Experimental biology and medicine (Maywood, N.J.)·2026
See all related articles

Exercise duration and intensity influence leptin levels, with prolonged activity suppressing this hormone. Long-term training can reduce leptin, especially in individuals with type 2 diabetes, impacting fat loss and metabolism.

Area of Science:

  • Exercise physiology
  • Endocrinology
  • Metabolic health

Background:

  • Leptin concentrations are influenced by various factors, including exercise, circadian rhythms, and energy balance.
  • Short-term exercise (<60 min) generally does not acutely affect leptin levels in healthy individuals.
  • Reductions in serum leptin are often linked to diurnal variations or hemoconcentration rather than acute exercise effects.

Purpose of the Study:

  • To investigate the effects of exercise duration, intensity, and training on leptin concentrations.
  • To explore the relationship between energy imbalance and leptin suppression.
  • To examine exercise-induced leptin adaptations in different populations, including patients with type 2 diabetes.

Main Methods:

  • Review of existing literature on exercise and leptin concentrations.

Related Experiment Videos

  • Analysis of studies differentiating between short-term (<60 min) and long-term (>=60 min) exercise.
  • Examination of training studies (<12 weeks and >12 weeks) and their impact on leptin.
  • Consideration of factors like fat mass, energy balance, insulin sensitivity, and lipid metabolism.

    • Main Results:

    • Long-term exercise (>=60 min) can reduce leptin, potentially due to diurnal variations or energy imbalance.
    • Significant energy imbalance suppresses 24-hr leptin rhythm in women.
    • Leptin reduction is observed 48 hours after long-term aerobic exercise and 9 hours after resistance exercise.
    • Short-term training (<12 weeks) has minimal effect, except in type 2 diabetes patients.
    • Long-term training effects on leptin are variable, often linked to fat loss, but some studies show reductions independent of fat loss.
    • Type 2 diabetes patients exhibit delayed and enhanced leptin responses to exercise training.

    Conclusions:

    • Exercise, particularly prolonged or intense activity leading to energy imbalance, can suppress leptin levels.
    • Leptin adaptations to exercise training are complex and influenced by factors like fat mass and insulin sensitivity.
    • Individuals with type 2 diabetes demonstrate unique sensitivities to exercise-induced leptin changes, suggesting potential therapeutic implications.