[Plasma insulin-binding capacity of diabetes mellitus patients with labile and stable courses]

Clinical picture of diabetes mellitus in the patients treated with insulin is characterized by a labile or stable course. It is supposed that of significance in the character of diabetes mellitus were antibodies formed in response to the exogenous insulin. Results of determination of the insulin-binding capacity of the blood plasma and of the antibody indices to insulin in the patients with a labile form of the disease antibodies with a low insulin-binding capacity circulated in the blood. Stable diabetes was characterized by the appearance in the blood of antibodies with a high insulin affinity, this being confirmed by an increase in the insulin-binding capacity of the blood plasma.