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General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate
European Journal of Clinical Pharmacology
|December 19, 1975
Abstract:
Steady state plasma drug concentrations can be achieved rapidly and safely by a drug input mode consisting of two consecutive constant rate intravenous infusions. A general method for calculating the relative rates of the two infusions is presented. The derivation is independent of the concepts of compartmental distribution and elimination of drugs within the body.