Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subdermal levonorgestrel implants: serum androgens.

M I Osman, M I Abdalla, M H Toppozada

    Contraceptive Delivery Systems
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Variations of the gallbladder in Sudanese subjects with literature review.

    Indian journal of medical sciences·2013
    Same author

    Exploring a mixture of distributions using Minitab.

    Computers in biology and medicine·1997
    Same author

    Responsiveness of the SF-36 and a condition-specific measure of health for patients with varicose veins.

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·1996
    Same author

    Integrated care for asthma: matching care to the patient.

    The European respiratory journal·1996
    Same author

    Estimating the point accuracy of population registers using capture-recapture methods in Scotland.

    Journal of epidemiology and community health·1996
    Same author

    SF 36 health survey questionnaire: I. Reliability in two patient based studies.

    Quality in health care : QHC·1994
    Same journal

    Premenopausal fertility score as a guide for individual anticonception.

    Contraceptive delivery systems·1984
    Same journal

    Studies on membrane-active vaginal spermicides.

    Contraceptive delivery systems·1984
    Same journal

    Prospective experience with a levonorgestrel implant--Norplant.

    Contraceptive delivery systems·1984
    Same journal

    Different approaches in contraception.

    Contraceptive delivery systems·1984
    Same journal

    Restovar--new low-dose, combined, oral contraceptive. Effects on serum proteins, free testosterone and clinical efficacy.

    Contraceptive delivery systems·1984
    Same journal

    Influence of Exluton (progestogen-only OC) and the Multiload Cu 250 IUD on lactation.

    Contraceptive delivery systems·1984
    See all related articles

    Subdermal levonorgestrel implants, a contraceptive method, were found to increase androstenedione and testosterone levels in women. These hormonal changes may be linked to adrenal or ovarian production and altered clearance rates.

    Area of Science:

    • Endocrinology
    • Reproductive Health
    • Pharmacology

    Background:

    • Subdermal levonorgestrel implants are a widely used hormonal contraceptive method.
    • Understanding the impact of these implants on endogenous hormone levels is crucial for assessing their overall physiological effects.
    • Androstenedione and testosterone are key androgens with potential clinical implications.

    Purpose of the Study:

    • To investigate the effects of subdermal levonorgestrel implants on serum levels of androstenedione, dihydrotestosterone, and testosterone in female volunteers.
    • To determine if contraceptive use of levonorgestrel implants alters androgen profiles.

    Main Methods:

    • Radioimmunoassay procedures were employed to measure serum hormone concentrations.
    • Serum samples were collected from 25 female volunteers at baseline and after 1 and 6 months of using levonorgestrel implants.
    Keywords:
    Age FactorsAndrogens--analysisBiologyContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive Agents--administraction and dosageContraceptive MethodsEndocrine SystemFamily PlanningHormonesInjectablesLevonorgestrel--administraction and dosageParityPhysiologyReproductive Control AgentsTestosterone

    Related Experiment Videos

    Main Results:

    • Mean serum androstenedione levels showed a significant increase after 1 month and a non-significant increase after 6 months compared to preimplantation levels.
    • Serum testosterone levels demonstrated an approximate 24% increase above basal values after 6 months of implant use.
    • The observed increase in testosterone was potentially linked to elevated androstenedione levels.

    Conclusions:

    • Subdermal levonorgestrel implant use can lead to alterations in androgen levels, specifically increasing androstenedione and testosterone.
    • The observed hormonal changes may result from increased production by the adrenal glands or ovaries, or alterations in hormone clearance rates.
    • Further research is warranted to fully elucidate the clinical implications of these hormonal shifts in women using levonorgestrel implants.