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[Contractile activity of the myocardium in chronic coronary insufficiency]
Insights
Chronic coronary insufficiency disrupts heart function and energy metabolism. Early detection of myocardial contractile dysfunction is key, even without overt heart failure symptoms.
Area of Science:
- Cardiology
- Biochemistry
Context:
- Investigated 69 patients with chronic coronary insufficiency, with and without cardiac decompensation.
- Examined myocardial protein composition and ATP-ase myosin activity in 31 ischemic heart disease patients.
Purpose:
- To investigate cardio- and hemodynamics in chronic coronary insufficiency.
- To identify early contractile dysfunction in the myocardium.
Summary:
- Radiocardiography and systolic phase analysis revealed significant cardio- and hemodynamic changes.
- Reduced actomyosin complex proteins and disturbed ATP-ase activity were observed, worsening with decompensation.
- These findings indicate impaired energy utilization and accumulation in the myocardium.
Impact:
- Enables early detection of myocardial contractile disorders in chronic coronary insufficiency.
- Highlights the link between energy metabolism defects and contractile dysfunction.
- Provides insights into the pathophysiology of ischemic heart disease progression.
Abstract:
Cardio- and hemodynamics was investigated in 69 patients with chronic coronary insufficiency without manifestations of cardiac decompensation and with symptoms of congestive incompetence of the heart by using radiocardiography and analyzing systolic phases of the left ventricle. Furthermore, fractional composition of myocardial proteins and the ATP-ase myosin activity were studied in 31 persons, who during their life-time suffered from ischemic heart disease. In patients presenting no symptoms of cardiac insufficiency significant changes in cardio- and hemodynamics along with a reduced content of the actomyosin complex proteins and their disturbed ATP-ase activity were uncovered. These changes proved more intensive in the face of manifestations indicating cardiac decompensation. Thus, a complex investigation of cardio- and hemodynamics enabled it to disclose initial disorders in the contractile activity of the myocardium in patients with chronic coronary insufficiency, when such disturbances are associated both with deranged utilization and with defective accumulation of energy in the myocardium.