[Trace element content in the blood and organs in arteriosclerosis]

Area of Science:

• Biochemistry
• Toxicology
• Cardiovascular Science

Background:

• Trace elements are essential for biological processes.
• Imbalances in trace elements have been implicated in various diseases.
• Atherosclerosis is a complex cardiovascular disease with multifactorial origins.

Purpose of the Study:

• To investigate the concentrations of 10 trace elements and lead in various organs of individuals with and without atherosclerosis.
• To determine if trace element profiles correlate with the presence and severity of atherosclerosis.
• To explore the potential role of trace elements in the pathogenesis of atherosclerosis.

Main Methods:

• Neutron-activation analysis was used to quantify 10 trace elements.
• Spectral analysis was employed to determine lead levels.
• Analysis was performed on whole blood and multiple organs (aorta, heart, liver, intestines, pancreas, adrenal glands, spleen, lungs) from accident victims.

Main Results:

• Individuals with atherosclerosis showed reduced levels of nickel, manganese, zinc, cobalt, vanadium, and iron in organs, particularly the aorta and liver.
• Elevated levels of lead, gallium, copper, bismuth, and bromine were observed in atherosclerotic individuals.
• These changes in trace element content were more pronounced with increased age and atherosclerotic progression.

Conclusions:

• Trace element dysregulation is associated with atherosclerosis.
• Specific trace elements, including iron, copper, and lead, may play a significant role in the development of atherosclerosis.
• Further research into trace element metabolism and its impact on cardiovascular health is warranted.