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Compositional changes of human mitral valves with aging.

Yoshiyuki Tohno1, Setsuko Tohno, Hiroyasu Satoh

  • 1Department of Anatomy, Nara Medical University, Kashihara, Japan.

Biological Trace Element Research
|September 28, 2002
PubMed
Summary
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Aging alters mitral valve composition, showing unique elemental correlations compared to other heart tissues. This study reveals how calcium, phosphorus, and magnesium levels change with age in the mitral valve.

Area of Science:

  • Cardiovascular Biology
  • Biogeochemistry
  • Gerontology

Background:

  • The aging process significantly impacts cardiovascular tissues.
  • Understanding elemental composition changes in heart valves is crucial for assessing cardiac health in the elderly.

Purpose of the Study:

  • To investigate the relationships among elemental contents within the mitral valve.
  • To compare the elemental composition of the mitral valve with the interventricular septum and sinoatrial node in aging individuals.

Main Methods:

  • Resection of mitral valves, interventricular septa, and sinoatrial nodes from deceased subjects (10 men, 15 women, aged 65-102).
  • Determination of elemental contents (Ca, P, Mg, Na, S) using inductively coupled plasma-atomic emission spectrometry.
  • Statistical analysis to identify significant correlations among element contents in different cardiac tissues.

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Main Results:

  • Mitral valves exhibited significant correlations among Calcium (Ca), Phosphorus (P), Magnesium (Mg), and Sodium (Na) contents.
  • No significant correlations were found between Sulfur (S) and Ca, P, or Mg in the mitral valve.
  • The interventricular septum showed significant correlations between P and S, Ca and Mg, Mg and S, and P and Mg, but not between Ca and P.
  • The sinoatrial node displayed significant correlations among Ca, P, Mg, and S.

Conclusions:

  • The elemental compositional changes in the aging mitral valve are distinct, with strong interrelations among Ca, P, Mg, and Na.
  • The mitral valve's elemental profile with aging appears intermediate between the thoracic aorta and the interventricular septum.
  • These findings contribute to understanding age-related cardiac tissue alterations and their biochemical basis.