Compositional changes of human mitral valves with aging

To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular septa, and terminal crests containing the sinoatrial nodes were resected and the element contents were determined by inductively coupled plasma-atomic emission spectrometry. The interventricular septa and sinoatrial nodes were used to compare with the mitral valves. With regard to the mitral valve, it was found that extremely significant correlations were found among the contents of Ca, P, Mg, and Na, but no significant correlations were found between the contents of S and elements such as Ca, P, or Mg. Regarding the interventricular septum, it was found that an extremely significant correlation was found between P and S contents; very significant correlations were found between Ca and Mg contents and between Mg and S contents; and a significant correlation was found between P and Mg contents. However, no significant correlation was found between Ca and P contents in the interventricular septa. In the terminal crest containing the sinoatrial node, significant correlations were found among the contents of Ca, P, Mg, and S. The present study revealed that with regard to the relationships among element contents, the compositional change of the mitral valve was intermediate between those of the thoracic aorta and the interventricular septum.