Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New terpenoid constituents from Eunicea pinta.

Yan-Ping Shi1, Abimael D Rodríguez, Charles L Barnes

  • 1Department of Chemistry, University of Puerto Rico, P.O. Box 23346, San Juan 00931-3346.

Journal of Natural Products
|September 28, 2002
PubMed
Summary

Researchers discovered eight new gamma-cembranolide diterpenes and a novel saponin from the octocoral Eunicea pinta. This finding necessitates revisions to existing cembranolide structures and shows potential for new drug leads.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Marine Pharmacology in 2022-2023: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities, Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Marine drugs·2026
Same author

Coordination of Anle138b to Silver Results in Selective Reduction of a C-Terminal Truncated α-Synuclein Protein and Increased Aggregate Size.

ChemMedChem·2026
Same author

An Acknowledgement to the <i>HCA Healthcare Journal of Medicine</i>'s Reviewers and Editors for the Second Half of 2025.

HCA healthcare journal of medicine·2026
Same author

"Coordination of Anle138b to Silver Results in Selective Reduction of a C-terminal truncated Alpha-synuclein Protein and Increased Aggregate Size."

bioRxiv : the preprint server for biology·2025
Same author

Discovery of Genetically Distinct, Sympatric Coral Lineages With Temporal but Not Gametic Reproductive Isolation.

Molecular ecology·2025
Same author

Democratized Discovery of Microsclerodermin F as an Immunophilin Ligand.

Marine drugs·2025

Area of Science:

  • Marine Natural Products Chemistry
  • Organic Chemistry
  • Pharmacognosy

Background:

  • The gorgonian octocoral Eunicea pinta is a marine invertebrate known to produce bioactive secondary metabolites.
  • Previous research on related species suggests a rich chemical diversity within Eunicea, but the specific composition of E. pinta remained undescribed.
  • Understanding the chemical constituents of marine organisms is crucial for discovering novel therapeutic agents.

Purpose of the Study:

  • To describe the secondary metabolite composition of Eunicea pinta from San Andrés Island, Colombia.
  • To isolate and characterize new and known compounds from this octocoral species.
  • To evaluate the cytotoxic and antimycobacterial activities of selected isolated compounds.

Main Methods:

Related Experiment Videos

  • Extraction and isolation of secondary metabolites from Eunicea pinta using chromatographic techniques.
  • Structure elucidation of isolated compounds through comprehensive spectroscopic analysis (NMR, MS) and X-ray diffraction.
  • Chemical conversions were employed to confirm structural assignments and stereochemistry.

    • Main Results:

    • Isolation of eight new gamma-cembranolide diterpenes (compounds 3-10) and one new saponin (compound 13).
    • Co-isolation of two known cembranolides: euniolide (1) and succinolide (2).
    • Structural determination confirmed the novelty of compounds 3-10 and necessitated revisions to proposed structures of related uprolide-type cembranolides and a stereochemical correction for succinolide (2).
    • Compounds 3, 4, and 13 exhibited cytotoxicity against various cancer cell lines.
    • Compounds 2, 4, and 13 demonstrated antimycobacterial activity.

    Conclusions:

    • The chemical investigation of Eunicea pinta has significantly expanded the known diversity of cembranolide diterpenes.
    • The structural revisions highlight the importance of rigorous characterization in natural product chemistry.
    • The isolated compounds, particularly the new diterpenes and saponin, represent promising leads for the development of anticancer and antimycobacterial agents.