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Low-dose lamotrigine in West syndrome
Carlo Cianchetti1, Dario Pruna, Giangennaro Coppola
1Child Neuropsychiatry, University of Cagliari, via Ospedale 119, I-09124 Cagliari, Italy. cianchet@unica.it
Epilepsy Research
|September 28, 2002
Abstract:
Three infants affected with symptomatic West syndrome (WS), unresponsive to gamma-vinyl-GABA and to ACTH (first line drugs for WS), were rapidly cured with very small doses of lamotrigine (LTG). This suggests the advisability of a trial with low-dose LTG, at least in symptomatic WS resistant to one or two first line drugs. Moreover, it may be of speculative interest as regards pathogenetic mechanisms in some cases of WS.