Purulent meningitis with unusual diffusion-weighted MRI findings
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Updated: Sep 29, 2026

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Published on: February 19, 2021
M Abe1, Y Takayama, H Yamashita
1Department of Neurology, Fukui Red Cross Hospital, 2-4-1 Tsukimi, Fukui 918-8501, Japan.
Abstract:
We describe unusual findings obtained by diffusion-weighted magnetic resonance imaging (MRI) in a patient with acute purulent meningitis caused by penicillin-resistant Streptococcus pneumoniae. Along cerebral convexities and the Sylvian fissure, multiple small intense lesions showed high signal intensity in these sequences. This may be the first report of diffusion-weighted in purulent meningitis.
Insights
Diffusion-weighted MRI revealed unusual lesions in a patient with penicillin-resistant Streptococcus pneumoniae meningitis. This imaging technique may offer new insights into diagnosing and understanding purulent meningitis.
Area of Science:
- Neurology
- Radiology
- Infectious Diseases
Background:
- Acute purulent meningitis is a serious infection requiring prompt diagnosis and treatment.
- Penicillin-resistant Streptococcus pneumoniae poses a significant challenge in clinical management.
- Diffusion-weighted magnetic resonance imaging (d-MRI) is a sensitive technique for detecting restricted diffusion in various neurological conditions.
Observation:
- A patient presented with symptoms suggestive of acute bacterial meningitis.
- Cerebrospinal fluid analysis confirmed purulent meningitis caused by penicillin-resistant Streptococcus pneumoniae.
- d-MRI was performed as part of the diagnostic workup.
Findings:
- d-MRI demonstrated multiple small, intensely hyperintense lesions.
- These lesions were predominantly located along the cerebral convexities and within the Sylvian fissure.
- The observed signal intensity suggests restricted diffusion within these areas.
Implications:
- This case may represent the first report of diffusion-weighted imaging findings in purulent meningitis.
- d-MRI may serve as a valuable tool for early detection and characterization of complications in meningitis.
- Further research is warranted to explore the role of d-MRI in the management of bacterial meningitis.
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Bacterial Meningitis I: Introduction
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Bacterial Meningitis II: Pathophysiology
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