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Interstitial nephritis with concomitant uveitis. Report of two cases
Contributions to Nephrology
|January 1, 1975
Summary
Pediatric uveitis can indicate kidney problems. In two girls, lymphocytes targeting kidney tubules caused interstitial nephritis, linked to uveitis and abnormal kidney function.
Area of Science:
- Nephrology
- Ophthalmology
- Immunology
Background:
- Uveitis, an inflammatory eye condition, can sometimes be associated with systemic diseases.
- Pediatric kidney diseases often present with proteinuria and glycosuria.
Observation:
- Two female pediatric patients presented with uveitis, proteinuria, and glycosuria.
- Kidney biopsies revealed interstitial nephritis in both cases.
Findings:
- Leukocyte migration inhibition tests showed sensitivity to renal tubular antigen, suggesting an autoimmune response.
- Elevated urinary beta2-microglobulin levels correlated with the clinical progression of uveitis.
Implications:
- This suggests a potential link between autoimmune tubulointerstitial nephritis and uveitis in children.
- Monitoring urinary beta2-microglobulin may aid in managing pediatric uveitis associated with kidney disease.