Related Experiment Video
Updated: Aug 2, 2026

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
Genetic diversity and models of viral evolution for the hepatitis C virus
1Department of Biology, University College London, Gower Street, London WC1E 6BT, UK. m.stumpf@ucl.ac.uk
Abstract:
In this review we discuss the application of theoretical frameworks to the interpretation of viral gene sequence data, with particular reference to the hepatitis C virus (HCV). The increasing availability of such data means that it is now possible (and necessary) to proceed from simple qualitative models of viral evolution, to more quantitative frameworks based on statistical inference, notably population genetics and molecular phylogenetics. We argue that these approaches are invaluable tools to the virologist and are essential for understanding the dynamics of viral infection and the outcome of therapeutic strategies. We use several recent HCV data-sets to illustrate the methods.
Related Concept Videos
Viral Recombination
Viral Mutations
Size and Structure of Viral Genomes
Viruses with RNA Genomes
Hepatitis
Viral Hepatitis I: Introduction

