Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclosporine can increase isoflurane MAC.

Claus U Niemann1, Caroline Stabernack, Natalie Serkova

  • 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA. niemannc@anesthesia.ucsf.edu

Anesthesia and Analgesia
|September 28, 2002
PubMed
Summary

The immunosuppressive drug cyclosporine increases the required dose of the anesthetic isoflurane in rats, contrary to initial hypotheses. This finding suggests cyclosporine may impact general anesthesia requirements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolite patterns in human urine after oral administration of highly purified Δ8-THCV.

Forensic toxicology·2026
Same author

Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation.

Trends in pharmacological sciences·2026
Same author

Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth.

Immunity·2026
Same author

A Retrospective Toxicology Study of Polysubstance Use Patterns Associated with Xylazine.

International journal of molecular sciences·2026
Same author

Endocannabinoids, perioperative pain, and acetaminophen in patients undergoing total knee arthroplasty: a prospective cohort study.

Pain reports·2026
Same author

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency.

Journal of inherited metabolic disease·2026

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Immunology

Background:

  • Cyclosporine, an immunosuppressive medication, has shown potential to influence anesthetic effects in prior studies.
  • Previous research indicated cyclosporine may potentiate sedative and analgesic effects of certain drugs.

Purpose of the Study:

  • To investigate if cyclosporine pretreatment alters the minimum alveolar concentration (MAC) of isoflurane in rats.
  • To determine if cyclosporine affects pain response as measured by hindpaw withdrawal latency (HPWL) to thermal stimulation.

Main Methods:

  • Rats were administered vehicle, 7.5 mg/kg/day cyclosporine, or 15 mg/kg/day cyclosporine for three days.
  • Isoflurane MAC was measured before and after the treatment period.
  • HPWL was assessed in control and high-dose cyclosporine groups post-treatment.

Related Experiment Videos

Main Results:

  • Cyclosporine significantly increased isoflurane MAC by 10.4% (7.5 mg/kg/day) and 23.1% (15 mg/kg/day).
  • The increase in MAC correlated with cyclosporine blood concentrations.
  • Cyclosporine did not significantly alter hindpaw withdrawal latency, indicating no significant analgesic effect.

Conclusions:

  • Contrary to initial hypotheses, cyclosporine pretreatment increases the dose of isoflurane needed to prevent movement to noxious stimuli in rats.
  • Cyclosporine does not appear to confer significant analgesia in this model.
  • These findings suggest cyclosporine may necessitate adjustments in anesthetic management.