Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer epigenomics.

Christoph Plass1

  • 1Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus OH 43210, USA. plass-1@medctr.osu.edu

Human Molecular Genetics
|September 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated multi-omic profiling reveals two distinct splenic marginal zone lymphoma subgroups with prognostic relevance.

Blood advances·2026
Same author

Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

Blood·2026
Same author

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.

Clinical epigenetics·2026
Same author

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition.

International journal of cancer·2026
Same author

Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD.

EMBO molecular medicine·2026
Same author

Happy birthday IJC.

International journal of cancer·2026
Same journal

Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.

Human molecular genetics·2026
Same journal

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026
Same journal

Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.

Human molecular genetics·2026
Same journal

Retraction: Aqua-soluble DDQ reduces the levels of Dr1 and Ab and inhibits abnormal interactions between Ab and Dr1 and protects Alzheimer's disease neurons from Ab- and Dr1-induced mitochondrial and synaptic toxicities.

Human molecular genetics·2026
Same journal

Retraction: Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss.

Human molecular genetics·2026
Same journal

Editor's Note: Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.

Human molecular genetics·2026
See all related articles

Cancer epigenomics research uses new technologies to study DNA methylation and chromatin modifications. Aberrant DNA methylation, especially genome-wide hypermethylation, is increasingly recognized as crucial in cancer gene regulation.

Area of Science:

  • Cancer epigenomics
  • Molecular biology
  • Genetics

Background:

  • Cancer gene discovery historically focused on genetic defects.
  • Epigenetic modifications, particularly DNA methylation, are now known to alter gene expression in cancer.
  • Chromatin modifications also play a significant role in gene regulation.

Purpose of the Study:

  • To review current knowledge of DNA methylation and histone modifications in normal cells.
  • To introduce the link between DNA methylation and chromatin modifications.
  • To highlight advancements in understanding aberrant DNA methylation in cancer.

Main Methods:

  • Review of existing research and recent data in cancer epigenomics.
  • Focus on DNA methylation and chromatin modification techniques.

Related Experiment Videos

  • Analysis of genome-wide methylation patterns.

    • Main Results:

    • Epigenetic modifications, including DNA methylation and histone modifications, are integral to gene regulation.
    • A strong interplay exists between DNA methylation and chromatin modifications.
    • Aberrant DNA methylation, especially genome-wide hypermethylation, is a key feature in cancer development.

    Conclusions:

    • Epigenetic mechanisms are critical in cancer development and progression.
    • Understanding the interplay between DNA methylation and chromatin modifications is essential for cancer research.
    • Genome-wide hypermethylation is a significant area of focus in cancer epigenomics.