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Published on: August 14, 2013
Physiopathological studies in septic rats and the use of fructose 1,6-bisphosphate as cellular protection
Fernanda Bordignon Nunes1, Melissa Guerra Simões Pires, José Carlos Farias Alves Filho
1Laboratório de Pesquisa em Biofísica, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil.
Objective:
The aim of this research project was to test the ability of fructose 1,6-bisphosphate (FBP), which has anti-inflammatory effects and maintains cellular energy levels, to inhibit the septic process in an experimental model in rats.
Design:
Prospective, controlled animal trial.
Setting:
Research laboratory.
Subjects:
Fed male Wistar rats.
Interventions:
Three experimental groups were formed for the test: control group, untreated septic group, and septic group treated with FBP (500 mg/kg).
Measurements And Main Results:
In the control group, there were no deaths; in the untreated septic group, the mortality rate was 100% within 15 hrs; in the septic group treated with FBP, the mortality rate reached 20% within 15 hrs. The blood cell tests revealed that concentrations of hematocrit, leukocytes, monocytes, and immature cells increased significantly in the untreated septic group compared with both the FBP-treated septic group and the control group. The histologic lesions verified in the heart, lungs, liver, and kidneys of septic animals were smaller and even absent in those treated with FBP.
Conclusion:
FBP reduced the mortality rate provoked by experimental sepsis and ameliorated hematologic and histologic alterations.
