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Related Experiment Videos

Between-eye asymmetry in keratoconus.

Karla Zadnik1, Karen Steger-May, Barbara A Fink

  • 1Ohio State University College of Optometry, Columbus 43210-1240, USA. zadnik.4@osu.edu

Cornea
|September 28, 2002
PubMed
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Keratoconus (KC) is characterized by significant asymmetry between eyes in corneal curvature, visual acuity, and refractive error. Unilateral eye rubbing or trauma is associated with increased asymmetry in keratoconic patients.

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Refractive Errors

Background:

  • Keratoconus (KC) is a progressive thinning of the cornea, leading to irregular astigmatism and visual impairment.
  • Understanding the asymmetry of KC is crucial for diagnosis, management, and predicting disease progression.
  • The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study provides valuable data on KC progression and characteristics.

Purpose of the Study:

  • To quantify baseline inter-eye differences in key visual and refractive parameters within the CLEK Study cohort.
  • To compare these differences with a control group of myopic contact lens wearers without ocular disease.

Main Methods:

  • Enrolled 1,079 KC patients and reviewed records of 330 myopic contact lens wearers.
  • Measured corneal curvature (keratometry), visual acuity (high and low contrast, best-corrected and entrance), and refractive error (spherical equivalent and cylinder).

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  • Assessed corneal scarring and patient-reported history of unilateral eye rubbing or trauma.

    • Main Results:

    • Significant mean inter-eye differences were observed in KC patients for keratometry (-3.59 to -4.35 D), visual acuity (7.30 to 9.43 letters), refractive error (spherical equivalent 3.15 D, cylinder 1.55 D).
    • Twenty-one percent of KC patients exhibited unilateral corneal scarring.
    • Unilateral eye rubbing and trauma correlated with greater asymmetry in corneal curvature and refractive error, with the affected eye being steeper.

    Conclusions:

    • Keratoconus exhibits significant asymmetry between the eyes in the CLEK Study cohort.
    • Patient-reported factors like unilateral eye rubbing and trauma are associated with increased ocular asymmetry in KC.