Is colic a gastrointestinal disorder?
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Updated: Sep 29, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
Published on: October 4, 2024
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202-5225, USA. sgupta@iupui.edu
Abstract:
Infantile colic is a distinct, although poorly defined, clinical entity. Whereas a general consensus regarding its cause is lacking, it is most likely multifactorial in genesis. Possible causative factors can be divided into two main groups: gastrointestinal and non-gastrointestinal. Food protein hypersensitivity or allergy is the leading contender in the former group, and disturbances in parental or maternal-child interactions in the latter. In all likelihood, the various factors act in tandem, leading to disturbances in infant gastrointestinal motility that manifests clinically as colic.
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