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Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in

M T El-Sherbiny1, O M Mousa, A A Shokeir

  • 1The Urology and Nephrology Center, Mansoura University, Mansoura, Eygpt.

The Journal of Urology
|September 28, 2002
PubMed

Insights

Transforming growth factor-beta1 (TGF-beta1) in urine aids in diagnosing pediatric kidney obstruction. While levels decrease post-surgery, further study is needed to confirm this trend for TGF-beta1 in obstruction management.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Biomarker Discovery

Background:

  • Pelviureteral junction obstruction is a common cause of kidney damage in children.
  • Accurate diagnosis and monitoring are crucial for preserving renal function.
  • Noninvasive diagnostic tools are highly desirable for pediatric patients.

Purpose of the Study:

  • To investigate the utility of transforming growth factor-beta1 (TGF-beta1) as a diagnostic marker for pediatric pelviureteral junction obstruction.
  • To assess the changes in urinary TGF-beta1 levels following surgical correction of the obstruction.

Main Methods:

  • Urinary TGF-beta1 levels were measured in children with confirmed pelviureteral junction obstruction and in a control group.
  • Samples included renal pelvic and bladder urine.
  • Bladder urine TGF-beta1 was re-evaluated 3 months after surgical intervention.

Main Results:

  • Renal pelvic urine TGF-beta1 was significantly higher than bladder urine in obstructed kidneys.
  • Bladder urine TGF-beta1 was significantly elevated in children with obstruction compared to controls.
  • A trend towards decreased bladder urine TGF-beta1 was observed post-surgery, though not statistically significant.
  • Urinary TGF-beta1 demonstrated 80% sensitivity, 82% specificity, and 81% accuracy for diagnosing obstruction.

Conclusions:

  • Urinary TGF-beta1 serves as a valuable noninvasive biomarker for diagnosing upper urinary tract obstruction in children.
  • Post-surgical follow-up shows a potential decrease in TGF-beta1 levels, suggesting its role in monitoring treatment response.
Abstract

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