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The role of caveolin-1 in androgen insensitive prostate cancer
Vladimir Mouraviev1, Likun Li, Salahaldin A Tahir
1Scott Department of Urology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA.
Purpose:
We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport.
Materials And Methods:
A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002.
Results:
Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer.
Conclusions:
The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.