Isolated acquired unilateral horizontal gaze paresis from a putative lesion of the abducens nucleus
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Updated: Sep 29, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Neil R Miller1, Valérie Biousse, Thomas Hwang
1Wilmer Eye Institute, Maumenee B-109, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA. nrmiller@jhmi.edu
Abstract:
In three patients, acute horizontal gaze pareses developed that could not be overcome with the oculocephalic maneuver, indicating a putative lesion of the ipsilateral abducens nerve nucleus. None of the patients had a facial nerve paresis or evidence of a trigeminal sensory neuropathy. Although most lesions that affect the abducens nerve nucleus also damage the ipsilateral fasciculus of the facial nerve, small lesions in this region can produce an isolated horizontal gaze paresis.
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