Related Experiment Video

Updated: Sep 29, 2026

Chromatin Immunoprecipitation from Dorsal Root Ganglia Tissue following Axonal Injury
09:41

Chromatin Immunoprecipitation from Dorsal Root Ganglia Tissue following Axonal Injury

Published on: July 20, 2011

Preferential expression of IGF-I in small DRG neurons and down-regulation following injury

Matthew J Craner1, Joshua P Klein, Joel A Black

  • 1Department of Neurology LCI 707 and PVA/EPVA Center for Neuroscience and Regeneration Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.

Neuroreport
|September 28, 2002
PubMed

More Related Videos

Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons09:42

Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons

Published on: August 17, 2012

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...