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Related Experiment Videos

Population dynamics during cell proliferation and neuronogenesis in the developing murine neocortex.

Richard S Nowakowski1, Verne S Caviness, Takao Takahashi

  • 1Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.

Results and Problems in Cell Differentiation
|October 2, 2002
PubMed
Summary

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During neocortex development, the pseudostratified ventricular epithelium (PVE) dynamically changes its cell cycle during the neuronogenetic interval (NI) to produce most neurons. This process explains neocortex expansion and laminar organization.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neocortex development involves significant cell proliferation in specialized ventricular zones.
  • The pseudostratified ventricular epithelium (PVE) is the primary source of neocortical neurons.
  • The PVE appears uniform but undergoes dynamic changes during neurogenesis.

Purpose of the Study:

  • To quantitatively analyze the dynamic changes in the PVE during the neuronogenetic interval (NI).
  • To understand how these changes contribute to neocortex expansion and neuronal laminar organization.
  • To investigate the role of maturation gradients in establishing neocortical areal borders.

Main Methods:

  • Mathematical modeling of cell cycle dynamics and progenitor output.
Keywords:
NASA Discipline Developmental BiologyNon-NASA Center

Related Experiment Videos

  • Analysis of cell cycle lengthening and exit rates during the NI.
  • Examination of developmental timing and spatial gradients across the PVE.

    • Main Results:

    • The PVE undergoes 11 cell cycles over 6 days during the NI, with lengthening cell cycle times.
    • Proportion of exiting progenitors increases, while re-entering progenitors decrease systematically.
    • Cells produced within specific developmental windows occupy distinct cortical laminae, with overlapping distributions from consecutive cycles.
    • A rostrocaudal maturation gradient across the PVE influences developmental timing.

    Conclusions:

    • Systematic changes in PVE cell cycle dynamics quantitatively explain neocortex expansion and cortical plate growth.
    • Developmental timing and output regulation during the NI are crucial for neuronal positioning and laminar structure.
    • Maturation gradients across the PVE may provide positional information for establishing areal boundaries in the adult neocortex.