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A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic
Oliver Langer1, Hanspeter Kählig, Karen Zierler-Gould
1Institut für Organische Chemie der Universität Wien, Währinger Strasse 38, A-1090 Wien, Austria.
The Journal of Organic Chemistry
|October 2, 2002
Abstract:
A cispentacin-derived bicyclic beta-amino acid (Bic) has been synthesized and incorporated into the 6-position of GnRH. The new GnRH analogue has been characterized with respect to its structure in solution and its activity and affinity toward the human GnRH receptor.