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Updated: Aug 17, 2026

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Gastrointestinal stromal tumors: chemotherapy and imatinib
Jeffrey H Muler1, Laurence Baker, Mark M Zalupski
1Division of Hematology/Oncology, University of Michigan, 1500 East Medical Center Drive, 3219 CCGC, Ann Arbor, MI 48109-0934, USA.
Abstract:
Gastrointestinal stromal tumors (GISTs), previously thought to arise from the smooth muscles of the gastrointestinal tract, have recently been identified as a separate clinicopathologic entity. This new entity was revealed when investigations using more refined techniques suggested that GISTs had neural rather than smooth muscle differentiation and expressed the cell surface receptor Kit (CD117). Ensuing research led to development of a new molecularly targeted therapy, imatinib mesylate, which showed significant response among GIST patients in initial clinical trials. This review describes treatment of GIST before and after imatinib and the significance of this accomplishment.
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