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Updated: Aug 12, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
RecQ helicases: at the heart of genetic stability
Jennifer A Cobb1, Lotte Bjergbaek, Susan M Gasser
1University of Geneva, Department of Molecular Biology, Quai Ernest-Ansermet 30, CH-1211, Geneva, Switzerland.
Abstract:
The checkpoint-mediated control of DNA replication is essential for maintaining the stability of the genome and preventing cancer in humans. The RecQ family of helicases has been shown to be important for the maintenance of genomic integrity in organisms ranging from bacteria to man. We propose that the RecQ homologue, Sgs1p, has an important function in the S-phase checkpoint response of budding yeast, where it may be both a 'sensor' for damage during replication and a 'resolvase' for structures that arise at paused forks. RecQ helicases may serve a unique function that integrates checkpoint proteins with the recombination and replication fork machinery.
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