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Related Experiment Videos

PPAR alpha stimulates the rat gastrin-producing cell.

Ingunn Bakke1, Tommy A Hammer, Arne K Sandvik

  • 1Department of Intra-abdominal Diseases, Norwegian University of Science and Technology (NTNU), NO-7489, Trondheim, Norway. igunn.bakke@medisin.ntnu.no

Molecular and Cellular Endocrinology
|October 2, 2002
PubMed
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Peroxisome proliferator-activated receptor alpha (PPARα) ligands stimulate stomach gastrin-producing cells (G-cells). This action, potentially mediated by PPARα in the stomach lining, increases gastrin levels and influences related cell growth.

Area of Science:

  • Gastroenterology
  • Molecular Endocrinology
  • Pharmacology

Background:

  • The peroxisome proliferator (PP) ciprofibrate stimulates gastrin-producing cells (G-cells) in the rat stomach, leading to hypergastrinemia and enterochromaffin-like (ECL) cell hyperplasia.
  • Ciprofibrate is a specific ligand for the nuclear peroxisome proliferator-activated receptor alpha (PPARα).

Purpose of the Study:

  • To investigate whether other PPARα ligands can mimic ciprofibrate's effects on G-cells and gastrin levels.
  • To explore the role of PPARα in mediating the gastric effects of ciprofibrate.

Main Methods:

  • Rats were administered PPARα ligand WY-14643 or PPARγ ligand troglitazone via gastric intubation for 28 and 56 days.
  • Gastrin mRNA abundance, G-cell density, ECL cell parameters, and acyl CoA-oxidase and PPARα mRNA levels were measured.

Related Experiment Videos

  • Immunostaining was used to detect PPARα receptor presence in G-cells.

    • Main Results:

    • WY-14643 increased gastrin mRNA, G-cell density, and hypergastrinemia, though less potently than ciprofibrate.
    • ECL cell changes correlated with hypergastrinemia.
    • Ciprofibrate and WY-14643 affected mRNA levels in the stomach antrum but not the corpus.
    • PPARα was detected in G-cells.

    Conclusions:

    • The study supports the hypothesis that PPARα-specific ligands can stimulate G-cells.
    • Local action within the stomach lumen via antral PPARα is a potential mechanism for G-cell stimulation by these ligands.