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Final infarct size after acute stroke: prediction with flow heterogeneity
Claus Z Simonsen1, Lisbeth Røhl, Peter Vestergaard-Poulsen
1Department of Neuroradiology, Arhus University Hospital, Nørrebrogade 44, DK-8000 Arhus C, Denmark.
Radiology
|October 2, 2002
Summary
Flow heterogeneity (FH) mapping may offer a more accurate prediction of final infarct volume in stroke patients compared to mean transit time (MTT) mapping. FH maps showed less overestimation of infarct size and were not significantly different from follow-up measurements.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Accurate prediction of final infarct volume in stroke is crucial for treatment decisions.
- Current methods like mean transit time (MTT) mapping have limitations in precision.
Purpose of the Study:
- To compare acute measurements of flow heterogeneity (FH) and MTT with follow-up data.
- To determine which method provides better predictive measures of final infarct volumes in stroke patients.
Main Methods:
- Twenty-three stroke patients underwent acute MR imaging.
- Tissue at risk was estimated using MTT maps and abnormal FH maps.
- Final infarct volumes were calculated from follow-up T2-weighted MR images.
- Wilcoxon signed rank test compared MTT and FH maps to follow-up data.
Main Results:
- Both MTT and FH maps predicted 10 of 11 cases with infarct growth.
- FH maps had fewer false positives (3) than MTT maps (5).
- FH maps overestimated infarct size by 15%, while MTT maps overestimated by 75%.
- FH map measurements showed no significant difference from follow-up (P =.059), unlike MTT maps (P =.005).
Conclusions:
- Flow heterogeneity (FH) mapping may provide a more precise prediction of final infarct volume.
- FH mapping demonstrates potential as a superior tool for acute stroke assessment.