Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels
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Désirée Griesemer1, Christian Zawar, Berthold Neumcke
1Physiologisches Institut, Universität des Saarlandes, Geb. 58/59, 66421 Homburg, Germany. phdgri@uniklinik-saarland.de
Abstract:
The contribution of ATP-sensitive potassium (K(ATP)) channels to neuronal excitability was studied in different types of pyramidal cells and interneurones in hippocampal slices prepared from 9- to 15-day-old rats. The presence of functional K(ATP) channels in the neurones was detected through the sensitivity of whole-cell currents to diazoxide, a K(ATP) channel opener, and to tolbutamide, a K(ATP) channel inhibitor. The percentages of neurones with K(ATP) channels increase in the sequence: CA1 pyramidal cells (37%)<
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