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[Suprasellar germinoma: two case reports].

Néjib Ben Abdallah1, Lotfi Cherif, Karima Khiari

  • 1Service de Médecine Interne A, Hôpital Charles Nicolle, 1006 Tunis, Tunisie.

La Tunisie Medicale
|October 3, 2002
PubMed
Summary

Suprasellar germinomas, common in young males, present with varied neuroendocrine and clinical issues. Radiotherapy significantly improves outcomes for this rare brain tumor.

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Area of Science:

  • Pediatric Oncology
  • Neuroendocrinology
  • Neurosurgery

Context:

  • Suprasellar germinomas are a type of germ cell tumor frequently diagnosed in children and adolescents, predominantly affecting males.
  • Clinical manifestations vary based on tumor location, often including increased intracranial pressure, visual disturbances, hypopituitarism, and Parinaud syndrome.
  • These tumors arise in the suprasellar region, impacting critical neurological and endocrine structures.

Purpose:

  • To report two cases of suprasellar germinoma in adolescent males.
  • To highlight the diverse clinical and neuroendocrine presentations of these tumors.
  • To emphasize the diagnostic confirmation and treatment approach.

Summary:

  • Two adolescent males (16 and 18 years old) presented with suprasellar germinoma.

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  • Case 1 exhibited corticotropin insufficiency, hypothyroidism, and hypogonadism.
  • Case 2 presented with hypocortisolism, hypothyroidism, hypogonadism, central diabetes insipidus, and hyperprolactinemia. Diagnosis was confirmed via surgery and stereotactic biopsy.
  • Treatment with radiotherapy was employed, demonstrating its efficacy in improving prognosis.

    • Impact:

    • This case series underscores the importance of recognizing varied neuroendocrine deficits in suprasellar germinomas.
    • Early diagnosis and appropriate treatment, particularly radiotherapy, are crucial for favorable outcomes in affected young patients.
    • The findings contribute to understanding the clinical spectrum and management of pediatric suprasellar germ cell tumors.