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Changes of coronary risk factors after eradication of Helicobacter pylori infection

Ye-Hsu Lu1, Hsueh-Wei Yen, Tsung-Hsien Lin

  • 1Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan.

The Kaohsiung Journal of Medical Sciences
|October 3, 2002
PubMed

Insights

Eradicating Helicobacter pylori (HP) infection did not significantly alter coronary risk factors like blood sugar, lipids, or fibrinolytic profiles in patients. Further research is needed to clarify the link between HP infection and coronary artery disease.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Epidemiological studies suggest a link between Helicobacter pylori (HP) infection and coronary artery disease.
  • Previous research indicates potential associations between HP infection and coronary risk factors.
  • Limited and conflicting clinical data exist on risk factor changes post-HP eradication.

Purpose of the Study:

  • To prospectively evaluate changes in sugar, lipid, and fibrinolytic profiles after successful HP eradication.
  • To investigate the impact of HP eradication on established coronary risk factors.

Main Methods:

  • Prospective study involving 48 patients with confirmed gastric HP infection.
  • HP eradication using a standard omeprazole-amoxicillin-clarithromycin (OAC) regimen.
  • Measurement and comparison of pre- and post-eradication blood sugar, lipid profiles, and fibrinolytic markers.

Main Results:

  • Successful eradication of HP infection was confirmed in all participants.
  • No statistically significant changes were observed in fasting blood sugar levels post-treatment.
  • Lipid profiles (total cholesterol, HDL, LDL, triglycerides) and fibrinolytic profiles (t-PA, PAI-1, fibrinogen, D-dimer) remained unchanged after HP eradication.

Conclusions:

  • Successful eradication of Helicobacter pylori does not appear to modify key coronary risk factors.
  • The relationship between HP infection and coronary artery disease requires further investigation.
  • Current findings suggest that HP eradication alone may not be sufficient to alter cardiovascular risk profiles.

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