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Related Experiment Videos

[Breast cancer].

Tadashi Ikeda1, Hiromitsu Jinno, Akira Matsui

  • 1Department of Surgery, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 3, 2002
PubMed
Summary
This summary is machine-generated.

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The Adjuvant chemo-endocrine therapy for breast cancer (ACETBC) trial was Japan's first large clinical study. Subsequent trials investigated oral 5-FU agents, showing marginal effects in adjuvant breast cancer treatment.

Area of Science:

  • Oncology
  • Clinical Trials
  • Pharmacology

Background:

  • The Adjuvant chemo-endocrine therapy for breast cancer (ACETBC) trial initiated in 1985 was Japan's first large-scale clinical trial.
  • Numerous prospective randomized trials have since been conducted in Japan, evaluating various treatment strategies.

Purpose of the Study:

  • To assess the efficacy of oral 5-fluorouracil (5-FU) agents in adjuvant settings for breast cancer.
  • To review the landscape of breast cancer clinical trials in Japan, including those using CMF chemotherapy as a control.

Main Methods:

  • Prospective randomized trials were employed to evaluate oral 5-FU agents.
  • Trials with CMF (cyclophosphamide, methotrexate, 5-fluorouracil) as a control arm were initiated following its government approval in 1996.

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Main Results:

  • A statistically marginal effect of oral 5-FU agents in adjuvant breast cancer treatment was reported in previous trials.
  • Results from several trials utilizing CMF as a control arm have not yet been published.

Conclusions:

  • Effective clinical trials require robust infrastructure, including clinical research coordinators.
  • Governmental regulations on anticancer agent dosage should be re-evaluated to facilitate better trial design and execution.