Related Experiment Video
Updated: Sep 29, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma
Juan A Asensio1, Walter Forno, Gustavo A Roldán Castillo
1Department of Surgery, University of Southern California School of Medicine and the Los Angeles County/USC Medical Center, Los Angeles 90033-4525, USA.
Abstract:
Ischemic optic neuropathy is a rare cause of blindness reported most commonly in association with collagen-vascular diseases, infectious processes, and systemic hypotension related to massive exsanguinating hemorrhage. We report what we believe to be the first case of posterior ischemic optic neuropathy due to perioperative hypotension in a patient who had a penetrating thoracoabdominal injury with massive hemorrhage, severe hypotension, massive microcapillary circulatory leak, multiple system organ failure, and acute respiratory distress syndrome. Although the incidence of postoperative visual loss is low (-0.002%), awareness of this entity must be raised within the trauma surgical community.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Glaucoma: Overview
Secondary Spinal Cord Injury llI: Pathophysiology
Hemorrhagic Stroke ll: Pathophysiology
