Related Experiment Videos
Differential accessibility at the kappa chain locus plays a role in allelic exclusion
Maya Goldmit1, Mark Schlissel, Howard Cedar
1The Hubert H.Humphrey Center for Experimental Medicine and Cancer Research, Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.
The EMBO Journal
|October 3, 2002
Abstract:
Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion.