The search is on for the voltage sensor-to-gate coupling

Optimization of novel compounds using computer-aided drug design for treatment of cardiac arrhythmia.

British journal of pharmacology·2026

A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology.

Structure (London, England : 1993)·2026

Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2025

Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia.

Journal of molecular and cellular cardiology·2025

Rescue of loss-of-function long QT syndrome-associated mutations in K<sub>V</sub>7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).

British journal of pharmacology·2025