Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does size matter?

William A Wells1

  • 1wellsw@rockefeller.edu

The Journal of Cell Biology
|October 3, 2002
PubMed
Summary
This summary is machine-generated.

Mammalian cells

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Converting donor dependence to domestic ownership: The realignment of tuberculosis financing for sustainability.

PLOS global public health·2026
Same author

Engaging private providers to enhance tuberculosis detection and notification: evidence from TB REACH-Supported projects.

BMC public health·2025
Same author

The Cost-Effectiveness of the BEAT-TB Regimen for Pre-Extensively Drug-Resistant TB.

Tropical medicine and infectious disease·2023
Same author

One year of COVID-19 and its impact on private provider engagement for TB: A rapid assessment of intermediary NGOs in seven high TB burden countries.

Journal of clinical tuberculosis and other mycobacterial diseases·2021
Same author

Realizing the "40 by 2022" Commitment from the United Nations High-Level Meeting on the Fight to End Tuberculosis: What Will It Take to Meet Rapid Diagnostic Testing Needs?

Global health, science and practice·2019
Same author

Meet the patients where they are: A greater ambition for private provider engagement for TB.

Journal of clinical tuberculosis and other mycobacterial diseases·2019
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

Area of Science:

  • Cell biology
  • Molecular biology
  • Genetics

Background:

  • The cell division cycle is fundamental to life.
  • A long-standing question in cell biology is whether cell division is regulated by cell size.
  • Existing models propose indirect mechanisms for cell size control.

Purpose of the Study:

  • To investigate the role of cell size monitoring in mammalian cell division.
  • To critically evaluate current models of cell cycle regulation.
  • To contribute to resolving the debate on cell size control.

Main Methods:

  • Review of existing literature and experimental data.
  • Analysis of theoretical models of cell cycle progression.
  • Comparative study of different mammalian cell types.

Related Experiment Videos

Main Results:

  • Evidence suggests cell size may not be a direct trigger for cell division in all mammalian cells.
  • Indirect mechanisms, influenced by various cellular factors, appear to play a significant role.
  • The precise mechanisms remain under investigation and debate.

Conclusions:

  • The question of direct cell size monitoring in mammalian cell division remains unresolved.
  • Current evidence favors indirect cell size regulatory mechanisms.
  • Further research is required to elucidate the definitive role of cell size in cell cycle control.