Myelin failure in multiple sclerosis: breaking the spell of Notch

Long-term safety and efficacy of ponesimod, an oral S1P1 receptor modulator, in relapsing-remitting multiple sclerosis (RRMS): Results from randomized phase 2b core and extension studies spanning up to 13 years.

Multiple sclerosis and related disorders·2026

Long-term safety and efficacy of ponesimod in participants with relapsing multiple sclerosis: results from the phase 3 OPTIMUM 5-year long term extension study.

Journal of neurology·2026

Ponesimod as add-on treatment in patients with active relapsing multiple sclerosis under dimethyl fumarate (POINT): A phase 3, randomized, placebo-controlled clinical trial.

Multiple sclerosis and related disorders·2025

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.

Proceedings of the National Academy of Sciences of the United States of America·2025

Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis.

Science immunology·2024

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis.

The Journal of experimental medicine·2022

Large-scale AI-guided liver malignancy diagnosis: multicenter study and a single-arm trial.

Nature medicine·2026

Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial.

Nature medicine·2026

Prospective evaluation of a large language model clinical decision support system in the emergency department.

Nature medicine·2026

Traumatic brain injury outcomes across human development index strata in 29 countries.

Nature medicine·2026

County, district and community-level measles transmission in the United States in 2013-2025.

Nature medicine·2026

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda.

Nature medicine·2026

Comparative Risk of Respiratory Virus Infections Among Patients with Asthma Treated with Biologic Therapies.

QJM : monthly journal of the Association of Physicians·2026

Biomarker-Guided Management in Vitreoretinal Diseases: Integrating Imaging, Pharmacotherapy, and Surgical Decision-Making-A Narrative Review.

Retina (Philadelphia, Pa.)·2026

Week 96 resistance analysis in participants receiving bictegravir/lenacapavir in the phase 2 ARTISTRY-1 study.

Antiviral therapy·2026

Industry updates in advanced therapy medicinal products and regenerative medicine - July 2026.

Regenerative medicine·2026

In Regulatory First, Myeloma Drug Approved Based on MRD Negativity.

Cancer discovery·2026

Structure and allostery in major facilitator superfamily symport mechanisms.

Acta crystallographica. Section D, Structural biology·2026

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Myelin failure in multiple sclerosis: breaking the spell of Notch

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Long-term safety and efficacy of ponesimod, an oral S1P1 receptor modulator, in relapsing-remitting multiple sclerosis (RRMS): Results from randomized phase 2b core and extension studies spanning up to 13 years.

Long-term safety and efficacy of ponesimod in participants with relapsing multiple sclerosis: results from the phase 3 OPTIMUM 5-year long term extension study.

Ponesimod as add-on treatment in patients with active relapsing multiple sclerosis under dimethyl fumarate (POINT): A phase 3, randomized, placebo-controlled clinical trial.

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.

Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis.

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis.

Large-scale AI-guided liver malignancy diagnosis: multicenter study and a single-arm trial.

Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial.

Prospective evaluation of a large language model clinical decision support system in the emergency department.

Traumatic brain injury outcomes across human development index strata in 29 countries.

County, district and community-level measles transmission in the United States in 2013-2025.

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda.

Comparative Risk of Respiratory Virus Infections Among Patients with Asthma Treated with Biologic Therapies.

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Myelin failure in multiple sclerosis: breaking the spell of Notch

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