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New cytotoxic bis-labdanic diterpenoids from Alpinia calcarata
Ling-Yi Kong1, Min-Jian Qin, Masatake Niwa
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P.R. China. lykong@jlonline.com
Planta Medica
|October 3, 2002
Abstract:
Two novel bis-labdanic diterpenoids named calcaratarin D and calcaratarin E were isolated from the rhizomes of Alpinia calcarata. Their structures were elucidated as a pair of stereoisomers on the basis of the spectral evidence. 2D NMR techniques including (1)H- (1)H COSY, HMQC, HMBC, NOESY spectra and HRFABMS were extensively applied to establish the structures. The two bis-labdanic diterpenoids showed cytotoxic activity against human KB cells in vitro.