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Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia
Alfredo Rosas-Romero1, Carlos Martinez Manchado, Oscar Crescente
1Departamento de Química, Universidad Simón Bolívar, Caracas, Venezuela.
Planta Medica
|October 3, 2002
Abstract:
Three sesquiterpene lactones were isolated from Lourteigia ballotaefolia (H. B. K.). 9beta-hydroxy-atripliciolide-8- O-tiglate ( 1) was isolated for the first time from this plant and was previously reported in Conocliniopsis prasiifolia (DC) K. et R., 9beta-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate) ( 2) had been already reported in this species. The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice.