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Chabamide, a novel piperine dimer from stems of Piper chaba
Thitima Rukachaisirikul1, Samran Prabpai, Penprapa Champung
1Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. thitima@ram1.ru.ac.th
Planta Medica
|October 3, 2002
Abstract:
A novel piperine dimer, named chabamide, was isolated from stems of Piper chaba Hunter and its structure was elucidated on the basis of spectroscopic evidence. Chabamide showed antimalarial activity with an IC(50) value of 2.7 microg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 microg/ml.