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A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS
Ljiljana Fruk1, Antonio Grondin, W Ewen Smith
1Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK G1 1XL.
Chemical Communications (Cambridge, England)
|October 3, 2002
Abstract:
Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles.