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[Ototoxicity induced by clarithromycin].

W Kolkman1, J H M Groeneveld, H J C M Baur

  • 1Medisch Centrum Haaglanden, locatie Westeinde, Postbus 432, 2501 CK Den Haag.

Nederlands Tijdschrift Voor Geneeskunde
|October 3, 2002
PubMed
Summary
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This study reports a case of hearing loss caused by the antibiotic clarithromycin. The hearing impairment was reversible and dose-dependent, suggesting clarithromycin-induced ototoxicity.

Area of Science:

  • Otolaryngology
  • Pharmacology
  • Infectious Diseases

Background:

  • Atypical pulmonary tuberculosis requires effective antibiotic treatment.
  • Macrolide antibiotics like clarithromycin are used for tuberculosis.
  • Drug-induced ototoxicity is a potential adverse effect of various medications.

Observation:

  • A 76-year-old male patient experienced progressive bilateral hearing loss.
  • Hearing loss onset occurred four days after initiating high-dose clarithromycin therapy.
  • Symptoms improved upon discontinuation and worsened with re-exposure.

Findings:

  • The patient's hearing loss demonstrated a clear dose-dependent relationship with clarithromycin.
  • Both subjective and objective hearing improvements were noted after dose reduction.

Related Experiment Videos

  • Full hearing recovery was achieved only after permanent cessation of clarithromycin.

    • Implications:

    • This case highlights clarithromycin as a potential cause of ototoxicity.
    • Clinicians should monitor for hearing changes in patients on clarithromycin.
    • Further research may be warranted to elucidate the mechanisms of clarithromycin-induced ototoxicity.