Related Experiment Video
Updated: Sep 29, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Ototoxicity induced by clarithromycin]
W Kolkman1, J H M Groeneveld, H J C M Baur
1Medisch Centrum Haaglanden, locatie Westeinde, Postbus 432, 2501 CK Den Haag.
Abstract:
A 76-year-old man developed a progressive bilateral hearing loss 4 days after starting a high dose of clarithromycin for atypical pulmonary tuberculosis. When the clarithromycin was discontinued the hearing improved subjectively but it worsened again upon reexposure. Halving the dose resulted in both an objective and subjective improvement in hearing, yet the original level of hearing was only obtained once clarithromycin had been permanently withdrawn. It would seem that this adverse effect is dose dependent. This seems to be the first published case study that demonstrates ototoxicity as a result of clarithromycin use.
More Related Videos
12:21The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
09:06Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
Published on: January 9, 2019
Related Concept Videos
Drug toxicity: Drug–Drug Interaction
Drug Toxicity: Dose-Dependent Reactions
Drug toxicity: Idiosyncratic Reactions
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Pharmacokinetics: Drug–Drug Interactions
Drug Toxicity: Risk factors