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Neuropathobiology in transgenic mice. The case of Alzheimer's disease

Jo Van Dorpe1, Kurt Spittaels, Chris Van Van den Haute

  • 1Experimental Genetics Group, Center for Human Genetics, Flemish Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium.

Methods in Molecular Biology (Clifton, N.J.)
|October 3, 2002
PubMed
Abstract

No abstract available in PubMed .

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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