Related Experiment Video

Updated: Aug 17, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Pulmonary volume recruitment restores pulmonary compliance and resistance in anaesthetized young children

R J Marcus1, J H van der Walt, R J A Pettifer

  • 1Department of Paediatric Anaesthesia, Women's and Children's Hospital, Adelaide, South Australia. ritchie.marcus@bhamchildrens.wmids.nhs.uk

Paediatric Anaesthesia
|October 3, 2002
PubMed

Insights

Timed re-expansion inspiratory maneuvers (TRIM) significantly increase pulmonary compliance in young children under general anesthesia. This maneuver offers a better alternative to 100% oxygen for improving lung function post-anesthesia.

Area of Science:

  • Pediatric Anesthesiology
  • Respiratory Physiology

Background:

  • General anesthesia impairs oxygenation and gas exchange.
  • A timed re-expansion inspiratory manoeuvre (TRIM) has shown promise in improving pulmonary compliance and oxygen saturation in lambs.

Purpose of the Study:

  • To evaluate the effect of TRIM on pulmonary compliance and airway resistance in children under general anesthesia.
  • To compare TRIM with 100% oxygen administration for improving lung function.

Main Methods:

  • Twenty children under 2 years received standardized ventilated general anesthesia.
  • Participants were randomized to receive either TRIM or 100% oxygen for 3 minutes.
  • Dynamic pulmonary compliance and airway resistance were measured.

Main Results:

  • Ventilated general anesthesia decreased pulmonary compliance by 12% and increased airway resistance by 12%.
  • 100% oxygen further reduced compliance by 9% (P=0.016).
  • TRIM significantly increased pulmonary compliance by 30% (P < 0.01), with no significant change in airway resistance.

Conclusions:

  • TRIM effectively increases pulmonary compliance during standardized ventilated general anesthesia in children.
  • TRIM is a superior method for improving pulmonary compliance compared to 100% oxygen in this pediatric population.
Abstract

More Related Videos

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

Related Concept Videos

Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Respiratory Volumes and Capacities01:22

Respiratory Volumes and Capacities

The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...