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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Association analysis of polymorphisms in the interleukin-4 receptor (alpha) gene with atopic asthma in patients from

K I Mújica-López1, S E Flores-Martínez, R Ramos-Zepeda

  • 1División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara Jalisco, México.

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
|October 3, 2002
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...