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Analysis of -631 and -475 interleukin-2 promoter single nucleotide polymorphisms in multiple sclerosis
M Fedetz1, A Alcina, O Fernández
1Instituto Parasitología & Biomedicina López Neyra, CSIC, Granada, Spain.
Abstract:
We have analysed the interleukin-2 (IL-2) promoter single nucleotide polymorphisms -475 A/T and -631 G/A, relative to the initiation codon, in patients with multiple sclerosis (MS) and in healthy controls. Both groups showed a very low frequency of T at -475 and A at -631. Our results suggest that these polymorphisms do not contribute to MS susceptibility.