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Lyme disease.

Patricia K Coyle1

  • 1Department of Neurology, School of Medicine, State University of New York at Stony Brook, HSC, T-12 Room 020, Stony Brook, NY 11794-8121, USA. pcoyle@notes.cc.sunysb.edu

Current Neurology and Neuroscience Reports
|October 3, 2002
PubMed
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Lyme disease, caused by Borrelia burgdorferi, presents diverse symptoms and can affect the nervous system. Antibody testing aids diagnosis, and antibiotics are effective for most patients.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Tick-borne Illnesses

Background:

  • Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi.
  • Infection risk is geographically limited to areas with the Ixodid tick vector.
  • The disease manifests in local, early dissemination, and late stages, affecting multiple organ systems.

Purpose of the Study:

  • To review the clinical manifestations of Lyme disease.
  • To discuss diagnostic challenges and the role of serology.
  • To highlight Lyme disease as a model for studying host-pathogen-vector interactions and infectious neurologic disease.

Main Methods:

  • Literature review of Lyme disease pathogenesis, clinical presentation, diagnosis, and management.
  • Analysis of the role of Borrelia burgdorferi in causing various disorders.

Related Experiment Videos

  • Examination of diagnostic controversies and the utility of antibody testing.

    • Main Results:

    • Lyme disease involves characteristic skin, musculoskeletal, cardiac, ocular, and neurologic disorders.
    • Neurologic involvement, affecting both central and peripheral nervous systems, can occur at any disease stage.
    • Difficulties in culturing Borrelia burgdorferi and lack of active infection assays complicate diagnosis, though seropositivity is common.

    Conclusions:

    • Antibody testing is valuable for supporting Lyme disease diagnosis due to high seropositivity rates.
    • Most patients achieve good outcomes with appropriate antibiotic treatment.
    • Lyme disease serves as a crucial model for understanding disease development and infectious neurological disorders.