Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice
Wieslawa Kosinska1, Edward Pelle, Marcia d M von Pressentin
1Department of Basic Sciences, New York University, Dental Center, 345 East 24th Street, New York, NY 10100, USA.
Cancer Letters
|October 3, 2002
Abstract:
Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.
