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Long-term follow-up of initially successful trabeculectomy with 5-fluorouracil injections
Ricardo Suzuki1, Christopher J Dickens, Andrew G Iwach
1Glaucoma Research and Education Group, San Francisco, California 94102, USA.
Purpose:
To study the long-term results (1-14 years) of trabeculectomies with 5-fluorouracil injections that were successful at 1 year.
Design:
A retrospective noncomparative case series. INTERVENTION/PARTICIPANTS: We identified 87 patients (87 eyes) who had trabeculectomies with 5-fluorouracil injections from 1984 to 1989 that were successful at 1 year and had a follow-up range of 1.0 to 14.7 years (mean, 8.1, standard deviation of 4.4 years). All patients had previously failed glaucoma surgery (66.7%), cataract surgery (47.1%), or other diagnoses making them at high risk for failure.
Main Outcome Measures:
Successful control of intraocular pressure (IOP) was defined as IOP less than 21 mmHg or a reduction of 33% if preoperative pressure was less than 21 mmHg. Statistical analysis was performed using Kaplan-Meier life table analysis.
Results:
If an eye is considered successful by IOP at 1 year, the probability of successful control is 61% at 5 years, 44% at 10 years, and 41% at 14 years.
Conclusions:
Despite successful IOP control at 1 year, trabeculectomies with 5-fluorouracil injections show a continual loss of IOP control over time.