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Updated: Jul 27, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
Published on: June 25, 2010
Cost-benefit analysis of universal tandem mass spectrometry for newborn screening
Edgar J Schoen1, John C Baker, Christopher J Colby
1Department of Genetics, Kaiser Permanente Medical Center, Oakland, California 94611-5693, USA. edgar.schoen@kp.org
Objective:
To estimate potential costs and benefits of routinely using tandem mass spectrometry (MS/MS) to screen newborns for inborn errors of metabolism.
Method:
Analysis of costs and benefits resulting from use of MS/MS in screening of 32 000 newborn infants using data from the Kaiser Permanente Medical Care Program of Northern California plus other published data.
Setting:
A large health maintenance organization.
Results:
In the base scenario, the cost per quality-adjusted life year saved by MS/MS screening was $5827; in the least favorable scenario, this cost was $11 419, and in the most favorable scenario, $736.
Conclusion:
Costs per quality-adjusted life year saved by MS/MS screening for inborn errors of metabolism compare favorably with other mass screening programs, including those for breast and prostate cancer.
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