Related Experiment Video
Updated: May 8, 2026

Vibratome Sectioning for Enhanced Preservation of the Cytoarchitecture of the Mammalian Organ of Corti
Published on: June 17, 2011
Furin at the cutting edge: from protein traffic to embryogenesis and disease
1Vollum Institute, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. thomasg@ohsu.edu
Abstract:
Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.
Related Concept Videos
Directing Proteins to the Rough Endoplasmic Reticulum
Protein Translocation Machinery on the ER Membrane
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the translocon complex.

